PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Abstract Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal cancer.Combining multiple complementary means, including in vitro and in vivo inflammatory

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Social Inclusion and Exclusion in the Life Stories of Deported Asylum Seekers from Finland to Iraqi Kurdistan

This Colour Tools study explores how social inclusion and exclusion manifest as a dynamic continuum in the everyday lived realities of irregular migrants.Based on narratives of Iraqi Kurdish asylum seekers, who were eventually deported from Finland, the analysis depicts the ways in which societal structures, personal negotiations as well as relatio

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Impact of the deep convection of isoprene and other reactive trace species on radicals and ozone in the upper troposphere

Observations of a comprehensive suite of inorganic and organic trace gases, including non-methane hydrocarbons (NMHCs), halogenated organics and oxygenated volatile organic compounds (OVOCs), obtained from the NASA DC-8 over Canada Headboard during the ARCTAS aircraft campaign in July 2008 illustrate that convection is important for redistributing

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